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Non-motor symptoms: the hidden burden Gastrointestinal dysfunction and the gut-brain axis PD may originate in the gut before manifesting in the central nervous system (CNS) through the formation of alpha-synuclein aggregates within the visceral nervous system

10.1007/s00709-011-0372-4 Protoplasma 73 KaurG.SinghH

Notably, high doses of Vitamin B (folic acid 0.8 mg, Vitamin B6 20 mg, Vitamin B12 0.5 mg) for 2 years was shown to slow the progression of brain atrophy significantly (Donnelly et al., 2008)

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