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Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells

PMID: 38319329

In ovariectomized rats and monkeys, weekly treatment with zoledronic acid dose-dependently suppressed bone turnover and prevented the decrease in cancellous and cortical BMD and bone strength, at yearly cumulative doses up to 3.5 times the human 5 mg intravenous dose, based on body surface area, mg/m2

However, in another study, in which 4F was administered by intravenous infusion or by subcutaneous injection, 4F failed to raise HDL antiinflammatory or antioxidant activities (Watson et al., 2011)

Individuals with aldehyde dehydrogenase 2 (ALDH2) deficiency, most prevalent in East Asian populations, accumulate acetaldehyde during alcohol metabolism, producing severe flushing, tachycardia, and nausea even at low intake levels