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In the melanocytes induced by H 2 O 2 , GP increased the activities of SOD and CAT, reduced the accumulation of ROS, thus increased the antioxidant capacity of melanocytes and inhibited melanocyte apoptosis by upregulating the Bcl-2/Bax ratio, while increasing cell viability

This process produces SAMe and recycles biopeterin

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Parallel to these endocrine perturbations, IR drives lipotoxicity and systemic inflammation, characterized by increased TNF-, IL-6, and C-reactive protein, which further suppresses insulin sensitivity and antioxidant enzyme expression (78)