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Serotonin reuptake inhibition: Enhances satiety signals Reduces appetite Improves mood (reduces emotional eating) Stabilizes cravings Similar to SSRIs but different profile Potency ratios: Why triple inhibition powerful: Attacks weight loss from multiple angles Metabolic + appetite + behavioral changes Synergistic effects stronger than single pathway But also multiplies side effect risks Different from GLP-1 single mechanism Compare to semaglutide mechanism and other weight loss approaches

Per ASCO guidelines, duloxetine is the only agent with moderate evidence for CIPN pain relief

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Improves the effectiveness of diet and exercise efforts

PMID: 108 TrefnyMPKroemerGZitvogelLKoboldS