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When the normality assumption was uncertain, as was determined for plasma cytokines, non-parametric KruskalWallis test and MannWhitney U test were used

Brain 136 , 32423251 (2013)

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Notably, the side chain-to-tail cyclized variant demonstrated potent anti-inflammatory activity and effectively reduced bacterial burden in a mouse skin infection model ( Figure 8 4.3 Terminal/side chain modifications N-terminal acetylation and C-terminal amidation ( Figure 9 ) are frequently employed strategies to enhance peptide stability by mitigating proteolytic degradation (Ting et al., 2020a)