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This gap underscores the need for tailored approaches, multidisciplinary care, and targeted research to address the specific needs of this population

We know from structural studies that due to its tetrameric nature, p53 requires a certain number of WT subunits to maintain functionality [35], and that many pathogenic p53 variants exhibit a dominant negative effect

Walker et al., 1991), and the second was the advent of molecular techniques, which led to the cloning, and characterization of the human GHR , thus initiating the understanding of the pathophysiology of GHI (Amselem et al., In medicine, scientific advances often move more rapidly than the practices of clinicians, who may remain attached to the recognized, and trusted view of a certain disorder, particularly if it is rare

doi: 10.1039/c2fo30097d