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Glutathione acts as a shield for the mitochondria, ensuring they can produce energy efficiently without being damaged by their own metabolic byproducts

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To explore this, we subjected proactive and reactive zebrafish to an acute novelty stressor and subsequently quantified changes in behavior and whole brain biomarkers of oxidative stress and antioxidants (DNA damage, total glutathione (GSH), glutathione ratio, oxygen radical absorbance capacity (ORAC), and superoxide dismutase (SOD)

In human colon cancer cells, PXR was shown to inhibit a crucial tumor-suppressing gene