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It is important to recognize that nephrotoxicity typically occurs 5-7 days after vancomycin initiation

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PMID: 36629979 Neurosci Bull Basal Forebrain Cholinergic Innervation Induces Depression-Like Behaviors Through Ventral Subiculum Hyperactivation

Please see also the XGBoost documentation for additional information on model parameters ( SHapley additive exPlanations (SHAP) analysis We interpreted our ML models and assigned relative importance to variables influencing circulating TMAO levels by co-opting SHAP values, as expanded for tree-based ML models 28 and recently used to objectively evaluate factors driving metabolite plasma levels in humans 23

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