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The nicotinamide mononucleotide (NMN), a phosphorylated intermediate in the synthesis of NAD can also be considered as a precursor since exogenous NMN administration raises NAD levels in various cell lines and tissues [68], and an NMN transporter (Slc12a8) has recently been identified in the murine small intestine [69]

Availability of data and materials Data sharing not applicable to this article Abbreviations B12: Vitamin B12 DOAJ: Directory of Open Access Journals HC: Haptocorrin Hcy: Homocysteine IF: Intrinsic factor IOM: Institute of Medicine MRI: Magnetic resonance imaging MS: Multiple sclerosis SCD: Sub-acute combined degeneration TCI: Transcobalamin I UL: Upper intake level References Aaron, S., Kumar, S., Vijayan, J., Jacob, J., Alexander, M., & Gnanamuthu, C