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Although protein-SSG formation occurs by nonenzymatic mechanisms, the de-glutathionylation of proteins is mainly catalyzed by Grxs 32

469 The mitochondrial protein sideroflexin 1 (SFXN1) is responsible for importing iron from the cytoplasm to the mitochondria, and SFXN1 deficiency leads to mitochondrial respiratory chain damage, affecting the biogenesis and assembly of complex III

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This protein can create an iron-overloaded environment and lay the foundation for the occurrence of cellular ferroptosis

FIGURE 2 Worthy of mention is that nuclear receptor coactivator 4 (NCOA4) can promote iron storage or release from ferritin and plays a crucial function in maintaining a dynamic balance of intracellular iron