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On the other hand, given that DNA methylation is potentially modifiable, and novel techniques to edit DNA methylation in specific genomic sites are emerging [50, 73, 89, 97], this reinforces the importance of knowing where in genome and in which cell-types disease-related changes occur, and could open new avenues for therapies targeting DNA methylation

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An exception was China, which, while being strikingly devoid of the Human-SFB-refML lineage, with a dataset of 21 separate projects and 205 SFB-positive samples, showed a clear mixed sample population of Human-SFB-refChicken and Human-SFB-refMouse at 32.7% and 59.5%, respectively, with 76% of bioprojects displaying a mixed SFB lineage designation (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] [126].Roychowdhury S, McMullen MR, Pisano SG, Liu X, Nagy LE