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Conclusion: Approximately 1 in 130 patients with MASLD had genomic evidence for hereditary dyslipidemia (both extremely high and low LDL-C), with rare pathogenic variants in APOB and LDLR being the most common

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Ther 2009, 17, 872879

Interestingly, deleterious effects of increased cardiolipin levels, including cardiolipin 68:5, have been associated to defective oxidative phosphorylation activity in MEGDEL syndrome, a rare neurometabolic disorder (Wortmann et al