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The other common polymorphism involves a Leu substitution in place of the more common Pro at amino acid 198 due to a substitution of T (codon, CTC) for a C (CCC)

The hypothesis regarding the dual conflicting roles of curcumin in carcinogenesis is further strengthened from their study as the lack of DNA damage was observed at low curcumin dose while elevated oxidative stress, DNA damage and the onset of cell death was evident at higher concentration of curcumin