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Weight loss effects of GLP-1RAs Liraglutide (3.0 mg, Saxenda), a GLP-1RA that activates the GLP-1 receptor, was approved by the FDA in December 2014 for adult obesity treatment [38] and has recently shown efficacy in adolescents aged 12 to 18 years

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It has been reported that in studies where high doses of milk thistle were taken for long periods of time, only 1% of people experienced any side effects, meaning that for the most part, milk thistle is relatively risk-free, as stated in the American Family Physician scientific journal: Aside from mild gastrointestinal distress and allergic reactions, side effects are rare, and serious toxicity rarely has been reported