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This indicates that cellular GSH availability is regulated by the CD73-mediated adenosinergic pathway (Figure 2D)

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The cyclic form is the product of nucleophilic attack by the oxygen of a hydroxyl group on the electrophilic carbon of the carbonyl group within the same molecule, producing a stable ring structure composed of five or six carbons that minimizes bond strain (Figure 24.21 "Fischer Projection and Haworth Projection of Glucose")

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Chang DM, Weinblatt ME, Schur PH: The effects of methotrexate on interleukin 1 in patients with rheumatoid arthritis