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Important Discontinuation Instructions In order to avoid developing withdrawal symptoms, instruct patients not to discontinue Hydrocodone Bitartrate and Acetaminophen Tablets without first discussing a tapering plan with the prescriber [see DOSAGE AND ADMINISTRATION] Maximum Daily Dose of Acetaminophen Inform patients not to take more than 4,000 milligrams of acetaminophen per day

Fibers, fermented in the colon, promote bacterial diversity, protect the mucosal barrier, and prompt production of SCFAs, positively maintaining gut microbial homeostasis and preventing inflammation (204206)

Small interfering RNA transfection Cells were transfected with Lipofectamine RNAiMAX (Invitrogen) as transfection reagent, together with 20 nM of the corresponding siRNA for 72 h, following the manufacturers instructions