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Su C, Cunningham RL, Rybalchenko N, Singh M (2012) Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling

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Shorter cycles (4-6 weeks) are sometimes used for cutting phases or competition preparation, while longer cycles (12-16 weeks) suit individuals with significant fat loss goals

Clinical trials have demonstrated significant efficacy, with patients losing approximately 15% of body weight with semaglutide 2.4 mg (STEP 1 trial) and up to 20% with tirzepatide (SURMOUNT-1 trial) when combined with lifestyle modifications

So maybe that's another reason that Elphaba doesn't like Dorothy