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doi: 10.1515/ijfe-2019-0233 96

When they detect a potential threat, such as an allergen, toxin, or pathogen, mast cells rapidly release powerful chemical mediators stored in granules within their cytoplasm

Torres-Aleman I: Targeting insulin-like growth factor-1 to treat Alzheimers disease

Conceptual and methodological pitfalls in experimental studies: an overview, and the case of Alzheimers disease

However, clinical trials with T4 gels at various concentrations (0.01, 0.02, 0.03, and 0.1%) in patients with pressure ulcers, venous leg ulcers, and epidermolysis bullosa showed no statistically significant difference in healing as compared to that of placebo, although some trends towards faster healing were noted at intermediate doses during early weeks [242,243]