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One concern with this approach is that many factors can influence the uptake of these sugars by epithelial cells, including (1) GI motility, (2) the use of medications such as nonsteroidal anti-inflammatory drugs, (3) intestinal transit time and surface area, (4) mucosal blood flow and (5) renal clearance

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Oxidative stress occurs when the excessive production of reactive oxygen species and reactive nitrogen species overwhelms the antioxidant systems ability to eliminate them 31