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In all regions of the eye, mtDNA damage is increased as a consequence of aging and age-related disease (Jarratt 2010)

Nature 436 123127 Ravanat JL, Turesky RJ, Gremaud E, Trudel LJ and Stadler RH 1995 Determination of 8-oxoguanine in DNA by gas chromatography-mass spectrometry and HPLC-electrochemical detection: overestimation of the background level of the oxidized base by the gas chromatography-mass spectrometry assay

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Methods: This study employed Mendelian randomization (MR) analysis and protein-protein interaction (PPI) networks to systematically explore the causal relationships between mitochondrial DNA copy number (mtDNA-CN) and specific mitochondrial proteins with DKA

KPV is a tripeptide, just three amino acids: lysine, proline, and valine