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mRNA-4157, a lipid-encapsulated personalized vaccine that encodes various neoantigens identified through a proprietary algorithm, was assessed as adjuvant monotherapy in patients with resected solid tumors (including melanoma, bladder carcinoma, HPV-negative HNSCC, NSCLC, SCLC, MSI-High, or TMB-High cancers) and in conjunction with pembrolizumab in patients with advanced or metastatic disease

For example, the study conducted by Mesquita et al

These cytokines also disrupt intracellular iron homeostasis, facilitating the accumulation of free iron and triggering ferroptosis [11]

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Nephrol Dial Transplant 17 Suppl 5: 3237, 2002 [DOI] [PubMed] [Google Scholar] 171.Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, and Isakson BE