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A prespecified analysis of this trial showed that a greater weight loss was associated with greater improvements in HF-related symptoms and physical limitations, regardless of patients age, gender and baseline body weight 89

Antidepressants were developed to create artificially elevated levels of the neurotransmitters that may improve mood, like serotonin and norepinephrine, even though the nearly 50-year-old hypothesis that depression is directly related to serotonin deficiencies has never been proven

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