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These metabolic pathways consist of methionine, urea cycle, glycine and serine, ammonia recycling, arginine and proline, aspartate, spermidine and spermine biosynthesis, betaine, alanine, malate aspartate shuttle, glutathione, and glutamate metabolisms (Figures 6A,B)

Recent advancements, including deep tissue fluorescence imaging, metabolomics, and mass spectrometry imaging, have enabled in vivo investigations of redox mechanisms in tumors, 526 but further research is needed to achieve full precision and efficacy

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TLR2 limits development of hepatocellular carcinoma by reducing IL18-mediated immunosuppression