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Cancer Res 66(11):58285835 Atwell LL, Hsu A, Wong CP, Stevens JF, Bella D, Yu TW, Pereira CB, Lhr CV, Christensen JM, Dashwood RH, Williams DE, Shannon J, Ho E (2015) Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract

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In SURPASS-2, the rates of all reported GI side effectsincluding nausea, diarrhoea, vomiting, dyspepsia, decreased appetite, constipation and abdominal painoccurring with tirzepatide (4044.9%) were generally comparable to those seen with semaglutide (41.2%) [9]

Passive Immunotherapy Two placebo-controlled phase 2 trials of monoclonal anti--synuclein antibodies ( prasinezumab and cinpanemab ) have also failed to meet their primary endpoints of change from baseline to week 52 or 76 in combined MDS-UPDRS part I + II + III scores [207, 208]