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thus, red blood cells in iron deficiency anemia appear hypochromic (less color) and microcytic (small) under microscopic examination (Urrechaga 2009)

With regard to the increased secretion of EVs during the progression of NAFLD, experimental studies demonstrated that toxic lipids significantly increase the production of hepatocyte-derived EVs, which act as mediators of paracrine signaling, causing hepatic stellate cell activation, angiogenesis and activation of macrophages leading to inflammation and chemotaxis [103,104,105]

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Fernndez-Real JM, Pearroja G, Castro A, Garca-Bragado F, Hernndez-Aguado I, Ricart W