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In the intrinsic pathway, attenuated Salmonella infection generates oxidative stress, which upregulates the pro-apoptotic Bax protein, downregulates the anti-apoptotic Bcl-2 protein, disrupts mitochondrial integrity, enhances cytochrome c release, and triggers caspase-9/3 cascade to induce apoptosis ( Salmonella can also modulate intracellular signaling pathways by inhibiting the pro-survival AKT/mTOR pathway and reducing NF-B activity to sensitize tumor cells to cell death and by activating the tumor suppressor p53 to enhance cell death signals ( Salmonella potently triggers apoptosis in tumor cells

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