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Exercise can also regulate synaptic transmission efficiency

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This is mechanistically demonstrated in breast cancer models, where SFN, by activating the Nrf2 pathway, reduces the secretion of prostaglandin E2 (PGE2) from tumor cells, thereby triggering MDSCs to switch from an immunosuppressive to an immunogenic phenotype and inhibiting their expansion (76)

Its anti-inflammatory profile, including suppression of TNF-alpha-dependent IL-6 secretion in dermal fibroblasts, [15] makes it appropriate even on sensitive, reactive, or post-procedure skin

It also helps slow the progression of arthritis.