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Inhibiting NNMT with 5-amino-1MQ reverses this: NAD+ levels rise, mitochondrial respiration increases, and white adipose tissue (fat storage) shifts toward thermogenesis

Johnson ME, Franks JM, Cai G, Mehta BK, Wood TA, Archambault K, Pioli PA, Simms RW, Orzechowski N, Arron S, Whitfield ML (2019) Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin

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Researchers continue to study how the drug may be combined with other therapies for positive patient outcomes

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