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1056,1057 Alpha-tocopheryl succinate (-TOS) inhibits complex II, inducing cytotoxicity in tumor cells by promoting electron leakage and ROS generation

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In a chronic constriction injury (CCI) model of NP in the sciatic nerve, researchers found that XO activity, which was often used to indirectly represent the level of ROS, was approximately four times higher on the operated side of the sciatic nerve than that on the sham-operated control and non-operated side (Khalil et al., 1999)

Pescatello LSFB, Fagard R, Farquhar WB, Kelley GA, Ray CA: Exercise and Hypertension

When dysregulated, the process can lead to the development of excessive cytokine release, termed cytokine storm [4]