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Cardiovasc Res 2016, 111 (2), 134-41

While linoleic acid is abundant in the skin, this is not the case with alpha-linolenic acid (ALA)

In cystine-starvation-induced and xCT-inhibition-induced ferroptosis, mitochondrial rupture, mitoROS production, and mitochondrial membrane potential (MMP) loss were observed, whereas these phenomena were not observed in GPX4 inhibitor-induced ferroptosis ( 2.2 Consequence of ferroptosis Some studies suggested that ferroptosis was a form of immunogenic cell death (ICD) ( 2.3 Regulators of ferroptosis Ferroptosis regulators perform in various manners, including iron uptake, iron export, and antioxidation

1i and Extended Fig Data

Targeted specificity was confirmed, as EphA2-negative cells showed no significant changes in EGFR expression or chemosensitivity