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In three phase 2 clinical ocular trials during which patients self-administered 0.1% T4 eye drops 2 to 6 times per day for 28 days reported no evidence of any adverse events

Among these metabolites identified are the polyamines, including spermine and spermidine

Consequently, the failure of endothelial-mediated vasodilatory activity characterized by shifting the vascular balance toward an abnormally constrictive, inflammatory, and prothrombombic state is regarded as one of the earliest manifestations of cardiovascular damage supporting the formation of atherosclerotic plaques [81]

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