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Targeting VEGF/VEGFR to decrease the number and function of immunosuppressive cells: Overexpression of VEGF in the TME is associated with intratumoral Tregs, which is associated with a poor prognosis [59]

For instance, building upon the established role of GPX4 in suppressing ferroptosis in alveolar cells, the demonstrated therapeutic potential of mesenchymal stem cell-derived exosomes, the feasibility of CD44-mediated macrophage targeting, and the precedent for pulmonary nucleic acid delivery, the engineering of inhaled exosomes to deliver GPX4 mRNA specifically to alveolar macrophages represents a promising frontier (175, 178)

Studies have examined the relationship between GHSR-1a stimulation by ipamorelin and subsequent liver IGF-1 production in rodent models, providing data on the pituitary-liver signaling axis

Daidzein, released by gut microbial -galactosidases, can suppress hepatocyte ferroptosis by reducing farnesyl diphosphate synthase expression [86]

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