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Giblin, F.J., Glutathione: a vital lens antioxidant

A recent study using MCAO in C57 mice found that a single pre-treatment with NFPS 24 h before ischemia significantly reduced infarct size and improved motor deficits, reinforcing that GlyT1 inhibition enhances neuroprotection by increasing GluN2A expression while decreasing GluN2B expression (Cavalcante et al

Concurrent extracellular acidosis resulting from anaerobic glycolysis and impaired perfusion reduces uptake of weakly basic chemotherapeutics through pH-dependent ion trapping, further limiting drug efficacy (135, 136)

Lastly, many studies included a mixed population (rheumatoid arthritis, psoriasis, and IBD), and no data were provided according to disease type [163,164,165]