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The choice between pen and vial is therefore above all a matter of how the reference material is stored and handled in the laboratory

Clarifying the difference of metabolic profiles and of molecular mechanisms between HFrEF and HFpEF might provide clinical significance of carnitine metabolism as new therapeutic target for metabolic disorder in hypertensive HFpEF, remaining unmet medical needs in cardiovascular medicine

[DOI] [PubMed] [Google Scholar] 132.Muller SL, Portwich M, Schmidt A, Utepbergenov DI, Huber O, Blasig IE, Krause G

Porcu M, Urbano MR, Verri WA Jr., Barbosa DS, Baracat M, Vargas HO, et al

Since Sp1 binds to specific GC-rich sequences in the promoter regions of its target genes to activate their transcription, a reduction in its DNA-binding ability due to zinc deficiency can result in the downregulation of these target genes [143]