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PLoS One 7(4):e35883 Kenchappa RS, Tep C, Korade Z, Urra S, Bronfman FC, Yoon SO et al (2010) P75 Neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor--converting enzyme/ADAM17

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Patients start at 2.5 mg weekly for 4 weeks, then escalate by 2.5 mg increments every 4 weeks as tolerated until reaching maintenance dose, typically 10 mg or 15 mg