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NNMT inhibitors may be used with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels, to produce synergistic or additive effects to provide muscular therapy

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Furthermore, ablation of SOX2 + cells resulted in few remaining acini by 8 days (Figs 2B and D, and EV2A), as shown by large regions of the ductal network completely devoid of AQP5 + cells (ducts are marked by dashed lines or KRT8 in Fig 2B)

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