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She also highlights the raft of molecules currently in development, including glucagon-based agents or triple agonists: It will be interesting to see how the field develops over the next couple of years, where were going to have a wealth of potential tools for us to use in the clinic. Key points: In REDEFINE 2, cagrilintide, an amylin analogue, was investigated in combination with the GLP-1 receptor agonist semaglutide due to its targeting appetite regulation in a complementary mechanism of action

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Taken together, these findings suggest that elevated CGRP in CF airways might be a compensatory mechanism to counter the lack of CGRP-mediated submucosal gland secretion

Schuckelt R, et al

The nuclear region was identified in the DAPI (blue) channel and similarly added to the ROI manager