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Furthermore, the administration of TNBS in 50% ethanol resulted in an additive injury with respect to either TNBS+saline or 50% ethanol, an effect that was accompanied by a significant depletion of mucosal GSH content

10.1016/j.tcb.2018.04.001 Trends Cell Biol

Some GSTs are capable of mediating the conjugation of the available sulfhydryl group of reduced glutathione (GSH) to the electrophilic central carbon atom of the isothiocyanate group 27,28,29,30

or non-enzymatic, being produced or consumed endogenously from food or supplements, thus interrupting the chain reactions of free radicals [20]