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On another hand, where IKE + DHAA is a potent inducer of ferroptosis, it is tempting to speculate that IKE + DHAA is rapidly depleting GSH, favoring strong GPX4 inactivation

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Indeed, we clearly demonstrate that cancer cells with high SLC7A11 levels were the least responsive to system x C inhibition

The transition of lens cortex into fiber cells during the developmental stages is characterized by biochemical changes which includes the synthesis of fiber-specific proteins, - and -crystallins, and arid morphologic changes such as cell elongation, loss of cellular organelles, and disintegration of the nucleus (Worgul et al