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B12 is important for making healthy red blood cells

Digestive disorders Conditions affecting the gastrointestinal system - such as inflammatory bowel disease (IBD), Crohn's disease, celiac disease, and autoimmune gastritis - can cause inflammation in the intestinal walls, damaging cells and impairing B12 absorption

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The latter arise from malabsorption from food-bound B12 induced by the hypochlorhydria associated with atrophic gastritis caused by the Helicobacter pylori, H pylori jnfection of the stomach (Sobczynska-Malefora et al., 2021)