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In the energy investment phase, glucose is first phosphorylated by hexokinase (HK) to form glucose-6-phosphate, which then undergoes isomerization to generate fructose-6-phosphate (F6P)

the quality of sleep (sleep disturbance) may be determined, inter alia, by asking the patient if he/she awakened tired or nonrefreshed never, seldom, often or usually, or always. Replies of often or usually or always may be scored as positive and other replies as negative

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Especially consider including anti-pseudomonal coverage at the start of treatment for clients with febrile neutropenia (Bakhshi & Besa, 2023)