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Another natural compound, trigonelline, a methylated form of nicotinic acid, is a newly discovered NAD + precursor able to increase NAD + in multiple species, with preclinical implications for use in sarcopenia, and for muscle and cognitive decline in aging 124,130,131

They achieve this by acting at the local level to repair ligaments, tendons, and gut tissues, while also promoting systemic healing through improved blood flow and muscle regeneration

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