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L-CN and GBB analyses were performed in MRM (Table 4), and each prepared sample was injected into ACQUITY HPLC BEH HILIC (1.7 um, 2.1 100 mm) column (Waters, 186003461, China) at a column temperature of 40 C for dissociation, and chromatography was performed using a gradient mobile phase consisting of water and 20 mM of ammonium formate (phase A) and acetonitrile (phase B) (Table 5)

Physicians in charge decided plasma sampling to measure plasma VPA concentrations, treatments and L-carnitine dose regimen, which included an intravenous 100 mg/kg loading dose followed by a maintenance dosing up to 3 g/day in 3 divided doses for 3 days (or until ICU discharge)

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In questo articolo, analizzeremo approfonditamente le controindicazioni della L-carnitina, sulla base delle attuali evidenze scientifiche