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Shift work cycle-induced alterations of circadian rhythms potentiate the effects of high-fat diet on inflammation and metabolism

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The mechanism of Riluzole effects in the treatment of ALS remains to be elucidated and may be related to the inhibition of glutamate release, the reduction of neuronal toxicity response, the stabilization of neuronal membranes and the blockade of voltage-sensitive sodium channels (11) to reduce the neuronal excitability

doi: 10.1016/j.cmet.2016.04.009

Itraconazole and fluconazole, though less extensively studied in children, appeared effective alternatives for both species, but their use requires caution due to potential hepatotoxicity and other adverse effects