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First, at the mechanistic level, single-cell spatial transcriptomics and metabolomics should be used to map ferroptosis pathways in nigral dopaminergic neurons, astrocytes, and microglia, with emphasis on the interplay between NCOA4-mediated ferritinophagy and -synuclein degradation, to build a dynamic model linking iron dysregulation, proteotoxic stress, and cell death

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Acquisition of a higher peak bone mass (PBM) in adolescence is associated with reduced subsequent fracture risk, whereas impaired acquisition of PBM or loss of bone in childhood is associated with greater fracture risk

It could be especially true when considering the abnormal tendency of misfolded SOD1 to accumulate on particular locations in the cell 96,97 , hence further increasing local H 2 O 2 concentration and accelerating the reaction by mass action