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Under glutamine-depleted conditions in the tumor microenvironment, autophagy mediates degradation of the IFN- receptor, impairing IFN- signaling and contributing to resistance against anti-PD-1/PD-L1 therapy (141)

This is consistent with earlier simulation work studying ubiquitin unfolding intermediates, which has found that the disruption of 1-5 or 5-3 pairing is the first event during ubiquitin unfolding 3335