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It is associated with microbial translocation from the gut into the interstitium and perivascular tissues resulting in systemic inflammation, abnormalities of lipid and glucose metabolism, atherosclerosis, and hypertension

5.1 Iron chelators and iron modifiers Iron chelators and modifiers effectively inhibit cellular ferroptosis by regulating the expression and activity of iron transporters and storage proteins, including transferrin and its receptor (TfR1), ceruloplasmin, ferroportin, divalent metal transporter 1 (DMT1), and other membrane iron transport proteins (24, 26)