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Myofibroblasts, the key effector cells in fibrosis, arise from fibroblasts, pericytes, endothelial cells, or epithelial cells via epithelialmesenchymal transition (EMT) under stimulation by transforming growth factor (TGF) -, clotting factors, and mechanical stress [11, 29, 34, 36]

Gefitinib inhibited the downregulation of ER by EGFR and restored the sensitivity of cells to tamoxifen to a certain extent (Jeong et al., 2019)

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The MND dosage was calculated based on the DOX concentration, and the final DOX concentrations were set at 2000, 1000, 500, 250, 125, 62.5, 31.25, 15.625, 7.813, and 0 ng/mL

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