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Such temporal separation matters for target-tissue exposure, since early absorbed conjugates will mainly affect circulating tissues, while colonic-derived metabolites may exert both local gut effects and delayed systemic effects (Zhang et al., 2024a, b)

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250,251,252 UA induced inflammation and relative mechanism Uric acid signaling triggers the activation of several transcription factors, such as NF-B or AP-1, through the activation of MAPK p38 and ERK pathways, resulting in the production of reactive oxygen species (ROS) under the conditions of hyperuricemia

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10.1021/acsnano.3c12796 46 HeJ.WangY.RenY.YuanQ.ZhangZ.LiL.et al (2024b)