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Toxicology of Quinone-Thioethers

Briefly, NPCs were collected and fixed with 4% PFA for 15 min on ice and then were centrifuged and washed with ice-cold PBS

The solution of JC-1 was freshly prepared at the time of analysis by dilution in DPBS (pH 7

This activity primarily occurs through the direct donation of electrons from functional groups and the enzymatic decomposition of superoxides, representing a fundamental defense mechanism against macromolecular damage

In muscles, the spinal cord, and the brain, the liver enzyme glutamine synthetase converts glutamate and ammonia (a toxic byproduct) into glutamine, protecting against ammonia toxicity